Valentine"s Day Gift Suggestions For Him - Jewellery The record of course goes on and on of program. There are also numerous innovative ideas that I haven"t mentioned, and that are however to be developed. The most interested ideas in my view are promoting a little organization or a music group. Let"s go more than these. Silly Bandz is only one particular brand underneath which these cool wristbands are sold. There are others. And they are well-known with youngsters of a lot of ages, even into large college. Even the drabbest meeting room at the neighborhood hotel can be manufactured festive. Why not decorate the space with printed wristbands balloons and streamers and add festive center pieces at each and every table. Then raffle off the centerpiece as a raffle in the direction of the end of your occasion. I want so badly that I could don"t forget the precise brand I first utilised as a child. The notion of taking part in Bloody Mary in a dark bathroom with luminescent hands appeared like just about the coolest factor in the world. Enchanting as this polish was, it had a horrible chalky texture that felt terrible when it rubbed against anything. Most females like to match their handbags with their sneakers, especially larger heels and sandals. You can select from various wedge sandals, flat sandals, considerable heel sandals, Indian sandals and gladiator sandals. Or if you like flip flops, you can pick from printed, plain or leather ones. The most famous example of this kind of campaign was Lance Armstrong Basis"s Dwell Robust yellow bands. The concept could seem outdated; even so, a lot of men and women still buy them. For illustration, this is a perfect concept to increase funds for school. Most students take pleasure in displaying their school spirit, regardless of whether it is by sporting a shirt, their school colors, and so forth. A wonderful way to raise funds is to promote wristbands with your school"s identify and/or mascot in your school colours. The perfect variety of bands to use for these projects is debossed wristbands. They rapidly grew to become a fad amongst large college students and just as speedily grew to become the topic of numerous PTA meetings. Within the previous handful of weeks, colleges across the country are banning these controversial bracelets simply because they really feel the message is not suitable for the little ones. If you"re hosing a raffle at your fundraising occasion, utilizing serial numbered wristbands with pull-off tabs are effortless to use and exciting for the participants. You basically apply the wristband to every person who buys an entry to your raffle and take away the detachable stub (like a ticket stub). The stub is entered into the raffle. When the winning numbers are announced, each and every person checks their own. No far more lost tickets! The winner will be wearing the ticket.

 

Luiz Philipe, who was born with microcephaly, sleeps in his house in Marica, Rio de Janeiro state, Brazil, on March 9, 2016. Brazil will adopt the World Health Organization (WHO) standards from the next week to determine if a baby has microcephaly, the Brazilian Health Ministry said on Wednesday. [Photo/Xinhua]


WASHINGTON -- Chinese researchers said Thursday they might have solved the mystery of why the Zika virus causes microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies.

In a study published in the US journal Science, a team led by Cheng-Feng Qin of the Beijing Institute of Microbiology and Epidemiology reported that one single genetic change, likely acquired in 2013, gave the mosquito-borne virus the ability to cause severe fetal microcephaly.

"Our findings offer a reasonable explanation for the unexpected causal link of Zika to microcephaly, and will help understand how Zika evolved from an innocuous mosquito-borne virus into a congenital pathogen with global impact," Qin said.

Zika was first identified in 1947 in Uganda, and until its recent emergence in the Americas, was a little known one that sporadically causes mild infections.

Then, it rapidly swept through South and Central America in 2015, and due to its link to congenital brain abnormalities, especially microcephaly during pregnancy, the World Health Organization declared in early 2016 the current epidemics a public health emergency of international concern.

However, scientists remain unable to determine why the virus evolved into a pathogen triggering severe neurological syndromes.

By comparing contemporary Zika virus strains from the 2015 and 2016 South American epidemics with an ancestral Cambodian virus that was circulating in 2010, Qin and colleagues found one critical mutation that conferred the ability to cause microcephaly in mouse models of fetal infection.

That one change, S139N, which replaced a serine amino acid with an asparagine at the 139th position of a Zika protein called prM, also made the virus more lethal to human neuron precursor cells in culture compared with the ancestral form.

Zika accumulated numerous changes throughout its genome between 2010 and 2016, of which S139N caused substantially more severe microcephaly and embryonic lethality in mouse models.

Evolutionary analyses revealed that the S139N change likely arose sometime around 2013, which coincided with initial reports of microcephaly.

It was then stably maintained during subsequent spread to the America.

"The discovery should provide guidance for the study of pathogenetic mechanisms of the Zika virus and for the development of vaccines and treatments," Qin said.

 


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